产品货号：
Z17288
中文名称：
FIP1L1抗体
英文名称：
Anti-FIP1L1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FIP1L1 Antibody |
| 指标别名 | Factor interacting with PAP;FIP1;FIP1 like 1 (S.cerevisiae);FIP1 like 1 protein;FIP1L1;FIP1L1 PDGFRalpha;hFip1;Rhe |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,ICC/IF,FCM,ELISA |
| 基因名称 | FIP1L1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human FIP1L1 recombinant protein (Position:E23-E558). |
| 实际分子量 | 72KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Factor interacting with PAPOLA and CPSF1 (i.e,FIP1L1;also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe,FIP1,and hFip1).This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors.This gene,the homolog of yeast Fip1 (factor interacting with PAP),binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity.Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain.An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor,alpha).The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA.This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES).This syndrome,recently reclassified as chronic eosinophilic leukemia (CEL),is responsive to treatment with tyrosine kinase inhibitors.Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Uniprot ID | Q6UN15 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | factor interacting with PAPOLA and CPSF1 |
| 蛋白名全称 | Pre-mRNA 3'-end-processing factor FIP1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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